Novel anisotropic MRI diffusion phantom
نویسندگان
چکیده
Diffusion MRI (DMRI) comprises a growing list of methods, and with that the need for a reliable and robust MRI phantom with which one can calibrate and validate them. In this study we developed a novel anisotropic diffusion MRI phantom and demonstrated its applicability by producing fractional anisotropy (FA) maps derived from DTI and average pore diameter maps using double Pulsed Field Gradient (d-PFG) filtered MRI. The DMRI phantom consists of eight water-filled glass capillary arrays (GCA) (Photonis, USA). The nominal pore diameter of two wafers is 10 μm; other two is 25 μm and the remaining four is 5 μm. DWI acquisition was used for DTI parameter estimations while double PFG filtered MRI was used for average pore diameter estimations. The ROI analysis of the d-PFG experiments yielded the expected average pore diameters and FA map. This phantom can be used to calibrate and validate various diffusion MRI methods. Furthermore, this work can provide a way to perform quality control or assurance tests in the clinic or in a biological research environment. By using a phantom with multiple pore diameters, methods developed to characterize cell size distributions such as AxCaliber MRI can also be validated.
منابع مشابه
P27 Calibrating d-PFG Filtered MRI Using a Novel Anisotropic Diffusion Phantom
Diffusion Phantom Michal Komlosh 1, Evren Ozarslan 1, Martin Lizak 1, Ferenc Horkay 1, Peter Basser 1 1 National Institute of Health Introduction: Diffusion MRI methods can provide valuable microstructural in formation about tissues and porous media within an imaging volume [1-3], how ever, calibrating them is problematic owing to the lack of suitable anisotropic diffusion MRI phantoms. Here ...
متن کاملAnisotropic phantom to calibrate high-q diffusion MRI methods.
A silicon oil-filled glass capillary array is proposed as an anisotropic diffusion MRI phantom. Together with a computational/theoretical pipeline these provide a gold standard for calibrating and validating high-q diffusion MRI experiments. The phantom was used to test high angular resolution diffusion imaging (HARDI) and double pulsed-field gradient (d-PFG) MRI acquisition schemes. MRI-based ...
متن کاملNoise-adaptive anisotropic diffusion filtering of MRI images reconstructed by SENSE (sensitivity encoding) method
SENSE (SENSitivity Encoding) imaging provides significant acquisition speedups in MRI. The main drawback of the method is that it generates images that have increased and spatially nonuniform noise levels and, hence, will often require retrospective filtering. In this paper, we show that standard anisotropic diffusion filtering, while being an effective technique for edgepreserving denoising of...
متن کاملAnisotropic conductivity tensor imaging in MREIT using directional diffusion rate of water molecules.
Magnetic resonance electrical impedance tomography (MREIT) is an emerging method to visualize electrical conductivity and/or current density images at low frequencies (below 1 KHz). Injecting currents into an imaging object, one component of the induced magnetic flux density is acquired using an MRI scanner for isotropic conductivity image reconstructions. Diffusion tensor MRI (DT-MRI) measures...
متن کامل